New Hair Research

"The advent of next-generation nutraceutical ingredients enables consumers to now use full-spectrum bioavailable botanicals with

proven clinical efficacy in combatting the underlying causes of thinning hair.

As such, it makes sense to rethink current medication-based protocols which are increasingly linked with undesirable side-effects with less harmful bioactive alternatives."

Dr. Sebastian Lighvani
Voted one of America’s Top Doctors every year since 2006

Our team of doctors and researchers spent years diving deeper into the root causes of thinning hair to uncover the truths and misconceptions about the science of hair loss – providing hope for thousands of men. Our research revealed a most welcome conclusion: THERE’S MORE AT PLAY THAN JUST DNA.

Common misperceptions about hair loss: New Science shows:

“Bad” genes inevitably lead to loss of hair and thinning HaIr in men

There is actually more at play than just DNA; so no one has to accept hair loss as their inevitable inheritance. After all, genetic predisposition simply means your follicles are more sensitive to a hormone that your body produces naturally and/or to the environment around you. Powerful botanicals are able to block this hormone and counter the effects of the environment on the hair.

Stress plays a role only in sudden hair loss.

Stress plays a leading role in ALL hair-health issues. In fact, science shows that elevated levels of chronic stress generate dangerous chemical molecules that disrupt hair growth cycle signaling and need to be addressed.

Genes and the Hormone Dihydrotestosterone (DHT) – the more potent form of testosterone – are the only culprits behind the most common form of hair loss in men.

Multiple triggers including DHT and other hormones, stress, environmental toxins (styling, products, tobacco), UV light, aging, nutritional deficiencies, inflammation and free radicals – can all dictate how your genes are expressed and how serious the hair loss becomes. All these triggers put the hair follicle out of balance, leading to a cascade of inflammation, free radicals and production of chemical molecules that alter hair growth cycle signaling.

Mono-targeting such as blocking androgen hormones like DHT or topicals that work only temporarily - is the standard of care.

A long-term solution requires that ALL the triggers at the root of hair loss and their consequences (inflammation, free radicals, damaging chemical molecules) be addressed in a multi-targeted, multi-step approach.

Mono-targeting with only vitamins and minerals, like biotin, can resolve hair loss.

While nourishing the follicles with vitamins and minerals is important, it is simply not enough to address all the triggers at the root of unhealthy follicles.

Acceptance that hair loss prevention comes with possible associated side effects.

Only pharmaceutical prevention is associated with troubling side effects because of over-suppression of DHT. Science shows that natural hair loss prevention with botanicals carries zero side effects, and delivers health benefits beyond your hair, including improved libido.


The hair follicle is a dynamic mini-organ that undergoes perfectly calibrated cycles of growth, regression and rest. Each follicle has its own independent biological clock that ticks and signals the follicle to grow hair, lose hair or lay dormant. When out of balance, under attack, or its environment is altered, the process of hair production is disrupted.

New science proves how a multitude of internal and external triggers create an imbalance in the body’s immune system and metabolic pathways. At the follicle, this produces a never-ending cascade of free radicals, oxidative stress and inflammation.

Chronic inflammation generates damaging molecules, more free radicals and results in injury to the follicle that disrupts hair growth. Injury prompts the follicle and the immune system to respond by producing more of these chemical molecules, called cytokines where the problem truly begins.


In our bodies, all communication happens through signaling molecules. In the follicles, too, very specific molecules are released to signal the follicle to either produce hair growth (anagen), regress (catagen), or rest (telogen).

Excess inflammation, free radicals and damaging chemical molecules disrupt the signaling molecules responsible for regulating the hair growth cycle and hair production.

Signaling Molecules — when not properly regulated — will disrupt a healthy hair- growth cycle and follicle growth by sending a signal to the follicle to move into catagen (regression) phase, rather than anagen (growth) phase; and anagen signaling is essential for these hairs to be replaced. This is the beginning of hair thinning. Simply put: You are not replacing the 100-200 hairs that normally fall out per day at the same rate.



In addition to the hair growth cycle being altered and the follicle now in an imbalanced state, the harmful inflammatory cascade leads to another important consequence:

  • The efficient delivery of nutrients to the follicle is compromised
  • The ability of the follicle to absorb nutrients is dramatically diminished

Our researchers coined the term DNAD or deficient nutrient absorption and delivery to describe the impoverished state of the follicle, which is essentially being starved as a result.

Comprehensive Solution in Four-Step Protocol

After years of research, the makers of NUTRAFOL® deduced that if a long-term solution to thinning hair and hair loss with sustainable efficacy were to exist, it would have to do the following:

  • STEP I
  • Synergistically target all potential triggering factors of hair loss.
  • STEP 2
  • Break the cascade of chronic inflammation and oxidative stress that disrupts hair growth, cycling and signaling.
  • STEP 3
  • Remove the follicle from the state of DNAD, recalibrate its signaling and optimize its environment - empowering it to heal.
  • STEP 4
  • Stimulate the growth cycle and provide the building blocks for healthy hair once balance is established.



THE CONCEPT OF MONO-TARGETING SINGLE TRIGGERS IS OUTDATED. Targeting single triggers with medications alone, such as those that target DHT, is not enough. Studies examining the extent of genetically predisposed hair loss in identical male twins showed that there are multiple lifestyle factors that dictate how those genes are expressed and how serious hair loss becomes. Potent therapeutic plants have been identified and now scientifically proven to target multiple triggers and offensive molecules that are sources of immediate injury and inflammation to follicles, such as DHT, stress hormones and free radicals. Studies show these nutraceutical-grade botanicals act as:
  • powerful stress adaptogens
  • natural DHT-blockers and hormone rebalancers
  • anti-oxidants and anti-inflammatories to multi-target the initial triggers at the root of hair health issues.
Without any side effects. 

THE CASCADE OF FREE RADICALS, INFLAMMATION AND DISRUPTIVE SIGNALING MOLECULES MUST BE BROKEN. It is not enough to simply remove the initial triggers once the inflammation cascade has begun as it will continue dysregulating normal hair growth, cycling and signaling. Powerful nutraceutical-grade botanicals with anti-inflammatory properties and anti-oxidants have been shown to significantly lower inflammatory bio-markers like CRP, as well as to combat free radicals and damaging inflammatory molecules that slow hair growth.

FOLLICLE HEALING MUST BE EMPOWERED BY BOOSTING AND OPTIMIZING THE BODY’S INNATE HEALING AND PROTECTIVE MECHANISMS. Our bodies have all they need to heal and protect us. But with age and with the challenges of daily life (triggers, inflammation, free radicals), the innate mechanisms that support healing (the immune and antioxidant systems) become depleted. Each follicle has an additional ability to shield itself from inflammation with a unique Immune Privilege. However this protective system, has now been shown to collapse from emotional and physical stress. So it is important to not only combat triggers and damaging molecules, but to also optimize the body’s natural mechanisms that promote healing and empower the follicle to remove itself from the state of DNAD.

The healing properties of potent therapeutic plants have also been proven to raise levels of the body’s natural (endogenous) antioxidant defenses, combat aging, increase factors that support the follicle Immune Privilege, and boost the immune system – empowering the damaged follicles to heal from within.

These same botanicals act to synergistically improve blood flow and the structural integrity of the scalp – supporting the follicle as it begins absorbing nutrients again.

GROWTH SHOULD BE SUPPORTED AND STIMULATED. In addition to providing vitamins, minerals and other nutritive building blocks, for healthy hair growth to occur, the hair growth cycle should be stimulated. It has been shown that these powerfully efficacious phyto-nutrients also have synergistic abilities to increase production of signaling molecules that normally stimulate the follicles to enter into anagen (growth phase of the hair cycle).

Nutrafol®, the patent-pending formulation, utilizes a full spectrum of standardized nutraceutical-grade phyto-nutrients, leveraging the multi-dimensional properties of powerful therapeutic plants that work in synergy to help slow and reverse hair thinning. Scientifically formulated, Nutrafol takes a four-stage approach to jumpstart your healthy hair growth cycle from the inside out - the 4Rs.